Research Articles
Unlocking Cancer's Defense System: The Dual Weapon Against Src and Abl Kinases
Discover how N(9)-arenthenyl purines act as dual Src/Abl inhibitors targeting multiple kinase states to combat cancer drug resistance.
The Great Escape: How Cancer Cells Evade Our Most Powerful Drugs
Discover how cancer cells use ABCB1 pumps to expel both chemotherapy drugs and their metabolites, creating powerful treatment resistance.
The Primate P-Glycoprotein: Decoding the Guardian of Our Cells
Explore the fascinating world of primate P-glycoprotein, a cellular guardian that protects our bodies from harmful substances and influences drug response.
Unlocking Nature's Slow Motion: How Scientists Are Outsmarting Malaria's Molecular Machinery
Discover how slow-onset enzyme inhibition is revolutionizing antimalarial drug development against Plasmodium falciparum Enoyl-Acyl Carrier Protein Reductase.
Chaetocin: How a Fungal Compound Could Revolutionize Treatment for Drug-Resistant Lung Cancer
Discover how chaetocin, a natural compound from fungi, shows promise in fighting drug-resistant non-small cell lung cancer by targeting transketolase and metabolic pathways.